Voniza 10

✔️ Voniza is prescribed for the treatment and prevention of various gastrointestinal conditions, including:

• Gastric ulcers and duodenal ulcers.
• Reflux esophagitis.
• Prevention of gastric or duodenal ulcer recurrence in patients on low-dose aspirin or NSAIDs.
• Adjunct therapy for Helicobacter pylori eradication in cases such as gastric or duodenal ulcers, gastric mucosa-associated lymphoid tissue (MALT) lymphoma, idiopathic thrombocytopenic purpura, post-endoscopic resection of early-stage gastric cancer, or Helicobacter pylori gastritis.

This medication should only be used under the guidance of a registered physician.

✔️ Dosage and Administration: Voniza 10

Gastric and duodenal ulcers:

• Dose: 20 mg orally, once daily.
• Duration: 8 weeks for gastric ulcers; 6 weeks for duodenal ulcers.

Reflux esophagitis:

• Initial treatment: 20 mg orally, once daily for 4 weeks. If necessary, treatment may be extended up to 8 weeks.
• Maintenance therapy: 10 mg orally, once daily. If insufficient, the dose may be increased to 20 mg daily.

Prevention of ulcer recurrence:

• With low-dose aspirin: 10 mg orally, once daily.
• With NSAID therapy: 10 mg orally, once daily.

Helicobacter pylori eradication (triple therapy):

• 20 mg Vonoprazan, 750 mg amoxicillin hydrate, and 200 mg clarithromycin, taken twice daily for 7 days.
• If the initial regimen fails, replace clarithromycin with 250 mg metronidazole (twice daily for 7 days).

Voniza can be taken with or without food.

✔️ Side Effects and Warnings: Voniza 10

1. Dizziness or Sleepiness may occur. Avoid driving or operating machinery unless fully alert.
2. Avoid alcohol consumption, as it may exacerbate drowsiness and increase stomach acid production.
3. Safety and efficacy in children have not been established.
4. If prolonged diarrhea occurs, consult your doctor immediately.

✔️ Precautions Before Use

Avoid taking Voniza 10 if you are allergic to its ingredients.

Inform your doctor if you have:

• Stomach tumors.
• Liver disease.
• A scheduled Chromogranin A blood test (as the medicine may interfere with test results).

1. Consult your doctor before use if you are pregnant or nursing.
2. Prolonged treatment may lead to:

• Low magnesium levels.
• Vitamin B12 deficiency.
• Increased risk of bone fractures.
• Clostridium difficile-associated diarrhea.

✔️ Drug Interactions with Voniza 10

• Drug-Drug Interactions: Voniza 10 may interact with:
  • Painkillers: Aspirin, naproxen.
  • Antidepressants: Duloxetine, amitriptyline.
  • Blood thinners: Clopidogrel.
  • Hypothyroid medications: Levothyroxine.
  • Anti-HIV drugs: Atazanavir.
  • Antifungals: Ketoconazole, itraconazole.
  • Anti-cancer drugs: Methotrexate.
  • Vitamin B12: Cyanocobalamin.
  • Sedatives: Diazepam, zolpidem.
• Drug-Food Interactions:
  • Avoid smoking and alcohol, as alcohol may aggravate acidity and heartburn.

✔️ Special Considerations

• Conditions to Report: Notify your doctor if you have:
  • Clostridium difficile-associated diarrhea.
  • Liver disease.
  • Bone fractures.
  • Hypomagnesemia (low magnesium).

✔️ Word of Advice: Voniza 10

• Monitor the course of the disease closely and use the minimum effective dose.
• Long-term use should include regular evaluations, such as endoscopy.
• Reevaluate the need for maintenance therapy in reflux esophagitis when the risk of recurrence is low.
• Use in pregnancy should only occur if the potential benefits outweigh the risks.
• It is recommended to avoid Voniza during breastfeeding. If essential, discontinue nursing.
• Dosage adjustments or discontinuation should be considered based on clinical response.

✔️ Use in Special Populations

• Elderly: Use with caution due to reduced hepatic and renal function.
• Children and adolescents (<18 years): Safety and efficacy not established; not recommended.
• Renal impairment:
  • Mild to moderate (eGFR 30-89 mL/min): No adjustment needed.
  • Severe (eGFR < 30 mL/min): Avoid use.
• Hepatic impairment:
  • Mild (Child-Pugh A): No adjustment needed.
  • Moderate to severe (Child-Pugh B or C): Avoid use.

✔️ Overdose Management

No specific data on overdose is available. Vonoprazan cannot be removed by hemodialysis. Treatment should focus on supportive and symptomatic care.

✔️ Storage

• Store below 30°C in a cool, dry place, protected from light.
• Keep out of reach of children.